Prescription Drop Off Prescription Drop Off: Do you have out of date prescription medications or medications you no longer use? Help keep your family and community safe by dropping off your unwanted medications at the Florence County Sheriff's Department, on Lake Avenue in Florence. The Sheriff's Department will safely dispose of these medications Proper disposal of unwanted prescriptions drugs keeps you and your family safe, and keeps the you and the community safe by keeping medications out of our pristine waterways and groundwater. The Sheriff's Department is open 24 hours per day, 7 days per week.